Description

4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine-2-Boronic Acid Pinacol Ester is a high-value, heterocyclic boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing complex carbon-carbon bonds under mild conditions. This compound is primarily needed by pharmaceutical R&D and agrochemical laboratories for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides requiring complex heterocyclic scaffolds.
• Material Science Research: Serves as a precursor for organic electronic materials and functional polymers.
• Cross-Coupling Reactions: Specifically designed as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to introduce the tetrahydropyrazolopyridine moiety.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Chemical Biology Probes: Utilized in the creation of molecular probes to study biological pathways and protein functions.

Basic Information

Product Name	4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1160615-37-1
Molecular Formula	C13H21BN2O2
Molecular Weight	248.13 g/mol
Synonyms	4,5,6,7-Tetrahydro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine; 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridine-2-boronic acid pinacol ester; Pyrazolo[1,5-a]pyridine-2-boronic acid, 4,5,6,7-tetrahydro-, pinacol ester; BRN 15319262
EINECS	Contact for details

Quality Control

Our 4,5,6,7-Tetrahydropyrazolo[1,5-A]Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research under stringent regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.