Description

4-(Hydroxymethyl)-3-Methylphenylboronic Acid Pinacol Ester is a key protected boronic acid derivative, essential for modern synthetic chemistry. Its primary value lies in its enhanced stability and solubility compared to the free boronic acid, making it a superior reagent for sensitive cross-coupling reactions. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A vital building block for creating biaryl and heterobiaryl structures in drug discovery and development.
• Pharmaceutical Intermediate Synthesis: Used in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Serves as a precursor for novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Employed in the synthesis of novel ligands for transition metal catalysis.
• Material Science: A monomer or precursor for organic electronic materials, such as polymers for OLEDs and OFETs.
• Chemical Biology & Proteomics: Utilized in the development of molecular probes and activity-based protein profiling (ABPP) reagents.

Basic Information

Product Name	4-(Hydroxymethyl)-3-Methylphenylboronic Acid Pinacol Ester
CAS No.	1160430-87-4
Molecular Formula	C15H23BO3
Molecular Weight	262.15 g/mol
Synonyms	3-Methyl-4-(hydroxymethyl)benzeneboronic acid pinacol ester; (3-Methyl-4-(hydroxymethyl)phenyl)boronic acid pinacol ester; 4-(Hydroxymethyl)-3-methylbenzeneboronic acid pinacol ester; Pinacol [4-(hydroxymethyl)-3-methylphenyl]boronate; 2-[4-(Hydroxymethyl)-3-methylphenyl]-5,5-dimethyl-1,3,2-dioxaborinane; B-[4-(Hydroxymethyl)-3-methylphenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 4-(Hydroxymethyl)-3-Methylphenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.