Description

2-Tetrahydropyranone-4-Boronic Ester is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in its utility as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Suzuki-Miyaura Cross-Coupling: A pivotal reagent for forming carbon-carbon bonds to create biaryl and heteroaryl structures central to many modern therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems.

Basic Information

Item	Details
Product Name	2-Tetrahydropyranone-4-Boronic Ester
CAS No.	1159919-02-4
Molecular Formula	C9H15BO3
Molecular Weight	182.03 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)dihydro-2H-pyran-2-one; 2-Oxo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)tetrahydro-2H-pyran; 2H-Pyran-2-one, tetrahydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)tetrahydro-2H-pyran-2-one; THP-Protected Boronic Ester; Pinacol ester of 2-Oxotetrahydropyran-4-boronic acid
EINECS	Contact for details

Quality Control

Our 2-Tetrahydropyranone-4-Boronic Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and GC to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.