Description

(3,3-Difluoro-Cyclobutyl)Methanamine HCl is a high-purity, fluorinated cyclobutylamine hydrochloride salt, a valuable building block in modern synthetic chemistry. Its unique structure, featuring a difluorocyclobutane ring, is critical for modulating the physicochemical properties of target molecules, such as lipophilicity, metabolic stability, and bioavailability. This advanced intermediate is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the difluorocyclobutyl moiety can enhance biological activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for chiral amines and ligands used in asymmetric catalysis and organometallic chemistry.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced materials where fluorine incorporation is desired for specific performance characteristics.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	(3,3-Difluoro-Cyclobutyl)Methanamine Hydrochloride
CAS No.	1159813-93-0
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	(3,3-Difluorocyclobutyl)methanamine hydrochloride; 1-(Aminomethyl)-3,3-difluorocyclobutane hydrochloride; 3,3-Difluorocyclobutanemethylamine HCl; (3,3-Difluoro-cyclobutyl)-methylamine hydrochloride; trans-(3,3-Difluorocyclobutyl)methanamine HCl; 3,3-Difluorocyclobutane-1-methanamine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (3,3-Difluoro-Cyclobutyl)Methanamine HCl is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure it meets the high standards required for research and development. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data for purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ISO guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.