Description

1-(tert-Butoxycarbonyl)Pyrrole-2-Boronic Acid Mida Ester is a sophisticated, protected boronic acid derivative designed for advanced synthetic applications. This compound is critical for enabling efficient, high-yielding cross-coupling reactions while offering superior stability and handling characteristics compared to its free boronic acid counterpart. It is an essential building block for medicinal chemists and process R&D teams in the pharmaceutical and agrochemical industries, facilitating the synthesis of complex heterocyclic targets, including active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heteroaryl linkages in drug discovery and API development.
• Medicinal Chemistry & Lead Optimization: Enables the rapid, modular assembly of diverse pyrrole-containing compound libraries for biological screening and structure-activity relationship (SAR) studies.
• Agrochemical Research: Used in the synthesis of novel pesticides and herbicides that incorporate the pyrrole heterocycle for enhanced biological activity.
• Material Science Precursor: Serves as a building block for creating organic electronic materials, such as conductive polymers or organic light-emitting diodes (OLEDs), where precise molecular architecture is required.
• Process Chemistry & Scale-up: The Mida ester protecting group provides improved stability, making this reagent suitable for multi-step synthesis and larger-scale manufacturing processes.

Basic Information

Product Name	1-(tert-Butoxycarbonyl)Pyrrole-2-Boronic Acid Mida Ester
CAS No.	1158984-94-1
Molecular Formula	C₁₄H₂₁BN₂O₅
Molecular Weight	308.14 g/mol
Synonyms	1-Boc-pyrrole-2-boronic acid MIDA ester; 2-(1-((tert-Butoxycarbonyl)-1H-pyrrol-2-yl)-1,3,2-dioxaborinan-5-one; N-Methyliminodiacetic acid (MIDA) boronate ester of 1-Boc-pyrrole-2-boronic acid; 1-Boc-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrrole; tert-Butyl 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-1H-pyrrole-1-carboxylate; Boc-Pyrrole-2-B(MIDA)
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxycarbonyl)Pyrrole-2-Boronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity, meeting the exacting standards required for research and development. Certificates of Analysis (COA) with full characterization data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.