Description

2-Thiopheneboronic Acid Mida Ester is a specialized organoboron reagent where the boronic acid functionality is protected by the N-methyliminodiacetic acid (MIDA) group. This protection is critical for its stability and utility in complex, multi-step synthetic sequences, particularly in cross-coupling reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel thiophene-containing compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boronic acid equivalent for the synthesis of biaryl and heterobiaryl systems containing the thiophene moiety.
• Pharmaceutical Intermediate: Key precursor in the research and development of active pharmaceutical ingredients (APIs) with thiophene-based scaffolds, which are common in various therapeutic agents.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that incorporate the thiophene heterocycle for enhanced biological activity.
• Material Science Research: Building block for the synthesis of conjugated polymers and organic electronic materials, where thiophene units are valued for their optoelectronic properties.
• Complex Molecule Construction: The MIDA ester's iterative cross-coupling capability makes it valuable for the controlled, sequential synthesis of complex polycyclic or dendritic structures.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules or probes for studying biological processes and target engagement.

Basic Information

Product Name	2-Thiopheneboronic Acid Mida Ester
CAS No.	1158984-92-9
Molecular Formula	C10H12BNO4S
Molecular Weight	253.08 g/mol
Synonyms	2-Thienylboronic Acid MIDA Ester; (2-Thienyl)-MIDA-boronate; N-Methyliminodiacetic Acid Boronate Ester of 2-Thiopheneboronic Acid; 2-Thiopheneboronic Acid N-Methyliminodiacetic Acid Ester; MIDA Boronate of Thiophene-2-boronic Acid; 2-Thienyl-B(MIDA); B-(Thiophen-2-yl)-N-methyliminodiacetic acid boronate
EINECS	Contact for details

Quality Control

Our 2-Thiopheneboronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 11B) and HPLC analysis, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.