Description

1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-1-Yl]Ethanone is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in oncology and other targeted therapy areas.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing reagent for constructing carbon-carbon bonds in complex organic synthesis.
• Pharmaceutical Intermediate: A crucial precursor in the research and development of novel active pharmaceutical ingredients (APIs), especially kinase inhibitors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying biological pathways and target validation.
• Agrochemical Synthesis: Potential intermediate in the development of advanced crop protection agents.
• Material Science Research: Can be used in the synthesis of organic electronic materials and functional polymers.

Basic Information

Product Name	1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-1-Yl]Ethanone
CAS No.	1158680-96-6
Molecular Formula	C15H19BN2O3
Molecular Weight	286.14 g/mol
Synonyms	1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-yl]ethanone; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-yl)ethanone; 1-Acetyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazol-1-yl methyl ketone; 1158680-96-6; 1-Acetyl-4-(pinacolatoboryl)-1H-indazole; 4-(Pinacolatoboryl)-1-acetyl-1H-indazole
EINECS	Contact for details

Quality Control

Our 1-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indazol-1-Yl]Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.