Description

3-Hydroxy-5-Nitrophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical protected intermediate in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex biaryl structures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and specialty chemical development.

Application

• Pharmaceutical Intermediate: A key protected boronic acid reagent for Suzuki cross-coupling in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biphenyl scaffolds.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology Probes: Utilized as a building block for synthesizing molecular probes and sensors that target biological systems.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Hydroxy-5-Nitrophenylboronic Acid Pinacol Ester
CAS No.	1158236-73-7
Molecular Formula	C₁₂H₁₆BNO₅
Molecular Weight	265.07 g/mol
Synonyms	5-Nitro-3-hydroxyphenylboronic acid pinacol ester; (3-Hydroxy-5-nitrophenyl)boronic acid pinacol ester; 2-(3-Hydroxy-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Hydroxy-5-nitrophenyl-Bpin; PINACOL 3-HYDROXY-5-NITROPHENYLBORONATE; B-(3-Hydroxy-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-5-Nitrophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable and can support regulatory documentation needs for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.