Description

Hydroxy Ipronidazole-D3 is a deuterium-labeled isotopologue of the nitroimidazole derivative, Hydroxy Ipronidazole. This stable isotope-labeled compound is a critical tool for quantitative bioanalytical research, providing unmatched precision in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug development and tracer analysis.

Application

• Internal Standard for LC-MS/MS: Serves as a high-purity, non-interfering internal standard for the accurate quantification of Hydroxy Ipronidazole and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for conducting mass spectrometry-based assays to study absorption, distribution, metabolism, and excretion (ADME) profiles of nitroimidazole drug candidates.
• Biomarker Research: Enables precise tracking and measurement of drug-derived compounds in preclinical and clinical trial samples.
• Method Development and Validation: Used as a reference material to develop, optimize, and validate robust analytical methods in compliance with GLP and FDA guidelines.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in IDMS protocols, which are considered the gold standard for achieving high accuracy and minimizing matrix effects in quantitative analysis.

Basic Information

Product Name	Hydroxy Ipronidazole-D3
CAS No.	1156508-86-9
Molecular Formula	C7H8D3N3O3
Molecular Weight	~188.18 g/mol
Synonyms	1-Methyl-2-(hydroxymethyl)-5-nitro-1H-imidazole-d3; 1-Methyl-2-(hydroxymethyl)-5-nitroimidazole-d3; Hydroxyipronidazole D3; [2H3]-Hydroxy Ipronidazole; Ipronidazole Metabolite M1-d3; Deuterated Hydroxy Ipronidazole; Stable Isotope Labeled Hydroxy Ipronidazole
EINECS	Contact for details

Quality Control

Every batch of Hydroxy Ipronidazole-D3 is manufactured and tested to meet the stringent requirements of research and bioanalytical applications. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications for identity, purity (by HPLC), isotopic enrichment, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.