Description

Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)-4,5-Dihydroimidazol-2-Ylidene][(Phenylthio)Methylene]Ruthenium(Ii)Dichloride is a highly specialized, second-generation Grubbs-Hoveyda type ruthenium-based metathesis catalyst. This compound matters for its exceptional activity and selectivity in challenging olefin metathesis reactions, including cross-metathesis (CM), ring-closing metathesis (RCM), and ring-opening metathesis polymerization (ROMP). It is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing complex molecules and polymers.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key ring-closing metathesis (RCM) steps in the production of active pharmaceutical ingredients (APIs) and complex macrocyclic compounds.
• Agrochemical Development: Facilitating the synthesis of novel, structurally complex fungicides, herbicides, and insecticides through efficient cross-metathesis (CM) reactions.
• Advanced Polymer & Material Science: Serving as a catalyst for ring-opening metathesis polymerization (ROMP) to create specialty polymers, functionalized materials, and self-healing composites.
• Fine Chemical & Specialty Chemical Production: Used in the synthesis of fragrances, flavors, and other high-value fine chemicals requiring precise stereochemical control.
• Academic & Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research within university and corporate laboratories.
• Process Chemistry Optimization: Employed in scaling up metathesis reactions from lab to pilot plant due to its improved stability and functional group tolerance.

Basic Information

Product Name	Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)-4,5-Dihydroimidazol-2-Ylidene][(Phenylthio)Methylene]Ruthenium(Ii)Dichloride
CAS No.	1155422-69-7
Molecular Formula	C48H66Cl2N2PRuS
Molecular Weight	912.05 g/mol
Synonyms	Grubbs-Hoveyda II Catalyst; Hoveyda-Grubbs Catalyst 2nd Generation; (1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene)dichloro(o-isopropoxyphenylmethylene)ruthenium (with tricyclohexylphosphine ligand); Dichloro[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene][(2-isopropoxyphenyl)methylene]ruthenium(II) (modified); Ru-based metathesis catalyst; CAS 1155422-69-7; HG-II Catalyst
EINECS	Contact for details

Quality Control

Our Tricyclohexylphosphine[1,3-Bis(2,4,6-Trimethylphenyl)-4,5-Dihydroimidazol-2-Ylidene][(Phenylthio)Methylene]Ruthenium(Ii)Dichloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure identity, purity, and catalytic performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and light-sensitive; prolonged exposure to air, moisture, or ambient light will degrade catalytic activity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Purple to brown crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Solubility	Soluble in common organic solvents (DCM, toluene, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.