Description

1-(Bromomethyl)-1-(Trifluoromethyl)Cyclopropane is a high-value, multi-functional organofluorine building block. This compound matters for its unique combination of a strained cyclopropane ring, a reactive bromomethyl handle, and a metabolically stable trifluoromethyl group, enabling the synthesis of complex molecules with tailored properties. It is primarily needed by researchers and process chemists in the pharmaceutical and agrochemical industries for advanced intermediate synthesis and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the cyclopropyl and trifluoromethyl motifs into active pharmaceutical ingredients (APIs), particularly in drug discovery for metabolic diseases and CNS disorders.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for synthesizing specialty monomers and polymers with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry Building Block: Utilized in exploratory organic synthesis to create diverse fluorinated compound libraries for screening.
• Cross-Coupling Reactions: The bromomethyl group participates in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.

Basic Information

Product Name	1-(Bromomethyl)-1-(Trifluoromethyl)Cyclopropane
CAS No.	1155272-93-7
Molecular Formula	C5H6BrF3
Molecular Weight	203.00 g/mol
Synonyms	1-(Bromomethyl)-1-(trifluoromethyl)cyclopropane; (1-(Bromomethyl)-1-(trifluoromethyl)cyclopropane; 1-Trifluoromethyl-1-bromomethylcyclopropane; Cyclopropane, 1-(bromomethyl)-1-(trifluoromethyl)-; (Trifluoromethyl)cyclopropylmethyl bromide; 1-(Trifluoromethyl)cyclopropanemethyl bromide
EINECS	Contact for details

Quality Control

Our 1-(Bromomethyl)-1-(Trifluoromethyl)Cyclopropane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and away from sources of ignition, strong acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.