Description

2H-1,4-Benzoxazine, 3,4-Dihydro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, heterocyclic boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile Suzuki-Miyaura cross-coupling reagent, enabling the efficient formation of carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable intermediates for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for novel drug candidates targeting CNS disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the benzoxazine scaffold's bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Probe Development: Employed in creating molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Academic & Contract Research: A vital reagent for synthetic methodology development and custom synthesis projects in academic and industrial R&D laboratories.

Basic Information

Product Name	2H-1,4-Benzoxazine, 3,4-Dihydro-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1155264-46-2
Molecular Formula	C₁₆H₂₂BNO₃
Molecular Weight	287.16 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine; 3,4-Dihydro-2H-1,4-benzoxazine-6-boronic acid pinacol ester; 2H-1,4-Benzoxazine-6-boronic acid, 3,4-dihydro-, pinacol ester; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-1,4-benzoxazine, 3,4-dihydro-; Benzoxazine pinacol boronate; 1155264-46-2
EINECS	Contact for details

Quality Control

Our 2H-1,4-Benzoxazine boronic ester is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analysis, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients in regulated industry segments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.