Description

5-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-2H-Benzo[1,4]Oxazine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient carbon-carbon and carbon-heteroatom bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of heterocyclic compounds with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides, leveraging its ability to introduce complex substituents into core structures.
• Material Science Research: Serves as a precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, where precise molecular design is crucial.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a versatile boronate ester coupling partner with aryl or vinyl halides to form biaryl and other conjugated systems under palladium catalysis.
• Chemical Biology & Medicinal Chemistry: Facilitates the rapid exploration of structure-activity relationships (SAR) in drug discovery programs through efficient library synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological development in synthetic organic chemistry and for scaling up target molecules from milligram to kilogram quantities.

Basic Information

Product Name	5-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-2H-Benzo[1,4]Oxazine
CAS No.	1154740-68-7
Molecular Formula	C14H19BClNO3
Molecular Weight	295.57 g/mol
Synonyms	5-Chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine; 2H-Benzo[1,4]oxazine, 5-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-; 5-Chloro-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine; 5-Chloro-6-(pinacolatoboryl)-3,4-dihydro-2H-1,4-benzoxazine; 5-Chloro-6-(pinacolboronato)-3,4-dihydro-2H-benzo[1,4]oxazine; CAS 1154740-68-7
EINECS	Contact for details

Quality Control

Our 5-Chloro-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-2H-Benzo[1,4]Oxazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural identity. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.