Description

5-Methyl-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-2H-Benzo[1,4]Oxazine is a high-value, advanced pharmaceutical intermediate featuring a benzoxazine core with a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl and heterobiaryl scaffolds. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of new active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates via palladium-catalyzed cross-coupling.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new chemical entities.
• API Development: Integral in the process development and scale-up of potential Active Pharmaceutical Ingredients (APIs).
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands and organometallic catalysts.
• Material Science: Potential monomer or precursor for advanced polymers and organic electronic materials.
• Agrochemical Research: Intermediate in the development of new herbicides or fungicides with complex aromatic structures.

Basic Information

Product Name	5-Methyl-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-2H-Benzo[1,4]Oxazine
CAS No.	1154740-49-4
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methyl-3,4-dihydro-2H-1,4-benzoxazine; 5-Methyl-6-(tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-benzo[b][1,4]oxazine; 5-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-1,4-benzoxazine; Benzo[1,4]oxazine, 5-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-; Pinacol 5-Methyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylboronate
EINECS	Contact for details

Quality Control

Our 5-Methyl-6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-3,4-Dihydro-2H-Benzo[1,4]Oxazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.