Description

3-Cyclopentyl-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Propanenitrile is a high-purity, advanced pharmaceutical intermediate featuring a versatile pyrazole-boronic ester pinacol ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions like the Suzuki-Miyaura reaction for constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-inflammatory therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester moiety makes it an essential reagent for forming carbon-carbon bonds, a fundamental step in constructing complex organic molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its structural complexity for targeted biological activity.
• Material Science: Serves as a building block for organic electronic materials and functional polymers requiring specific heterocyclic architectures.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) agents.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	3-Cyclopentyl-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Propanenitrile
CAS No.	1153949-38-2
Molecular Formula	C17H26BN3O2
Molecular Weight	315.22 g/mol
Synonyms	3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile; 3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propanenitrile; 1H-Pyrazole-1-propanenitrile, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclopentyl-; 1153949-38-2; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclopentyl-1H-pyrazole-1-propanenitrile; Boronic acid, B-[1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Cyclopentyl-3-[4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Propanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.