Description

3'-Fluoro-4'-(1H-Pyrazol-1-Yl)Acetophenone is a high-purity fluorinated acetophenone derivative featuring a pyrazole substituent, serving as a critical advanced pharmaceutical intermediate (API intermediate). This compound matters for its role in constructing complex molecular architectures, particularly in medicinal chemistry for the development of novel therapeutic agents. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise building block to synthesize potential drug candidates targeting a range of diseases, where its specific fluorine and heterocyclic motifs are essential for modulating biological activity and pharmacokinetic properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities in drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides, leveraging the biological activity of the fluoropyrazole moiety.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands for catalysis or functional organic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of tailored compounds for client projects.

Basic Information

Item	Detail
Product Name	3'-Fluoro-4'-(1H-Pyrazol-1-Yl)Acetophenone
CAS No.	1152964-31-2
Molecular Formula	C11H9FN2O
Molecular Weight	204.20 g/mol
Synonyms	1-[4-(1H-Pyrazol-1-yl)-3-fluorophenyl]ethanone; 3-Fluoro-4-(1H-pyrazol-1-yl)acetophenone; 1-(3-Fluoro-4-(1H-pyrazol-1-yl)phenyl)ethan-1-one; 3'-Fluoro-4'-(pyrazol-1-yl)acetophenone; 4-(1H-Pyrazol-1-yl)-3-fluoroacetophenone; 3-Fluoro-4-(1-pyrazolyl)acetophenone; 1152964-31-2
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-(1H-Pyrazol-1-Yl)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.