Description

2-(2,6-Difluorophenyl)Thiazole-5-Carboxylic Acid is a high-value, multi-functional heterocyclic building block featuring a difluorophenyl group and a carboxylic acid moiety. This compound is essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its specific fluorine substitution pattern is critical for modulating biological activity and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and anti-inflammatory drug discovery.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the fluorine atoms enhance lipophilicity and metabolic stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of organic semiconductors and liquid crystal materials due to its rigid, conjugated thiazole core.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring precise fluorinated heterocyclic architectures.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	2-(2,6-Difluorophenyl)Thiazole-5-Carboxylic Acid
CAS No.	1152614-44-2
Molecular Formula	C10H5F2NO2S
Molecular Weight	241.22 g/mol
Synonyms	5-Thiazolecarboxylic acid, 2-(2,6-difluorophenyl)-; 2-(2,6-Difluorophenyl)-1,3-thiazole-5-carboxylic acid; 2-(2,6-Difluorophenyl)-5-carboxythiazole; 1152614-44-2; 2,6-Difluorophenyl thiazole-5-carboxylic acid; DFPTCA; 2-(2,6-Difluorophenyl)thiazole-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(2,6-Difluorophenyl)Thiazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.