Description

1-(Bromomethyl)-2-(2,2,2-Trifluoroethoxy)Benzene is a high-value, multi-functional aromatic building block featuring both a reactive benzyl bromide and a trifluoroethoxy group. This compound is essential for advanced organic synthesis, enabling the introduction of fluorinated ether moieties into target molecules, which can dramatically alter their physicochemical and biological properties. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly those requiring trifluoroethoxy-substituted aromatic systems to modulate lipophilicity, metabolic stability, and receptor binding.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoroethoxy group enhances biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis or as a building block for functional materials.
• Fluorinated Liquid Crystal Research: Employed in the synthesis of fluorinated aromatic cores for high-performance liquid crystal materials used in display technologies.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and library generation for drug discovery.

Basic Information

Product Name	1-(Bromomethyl)-2-(2,2,2-Trifluoroethoxy)Benzene
CAS No.	1152553-26-8
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	2-(Bromomethyl)-1-(2,2,2-trifluoroethoxy)benzene; α-Bromo-2-(2,2,2-trifluoroethoxy)toluene; 1-(Bromomethyl)-2-(trifluoroethoxy)benzene; o-(Trifluoroethoxy)benzyl bromide; 2-(2,2,2-Trifluoroethoxy)benzyl bromide; (2-(2,2,2-Trifluoroethoxy)phenyl)methyl bromide
EINECS	Contact for details

Quality Control

Every batch of 1-(Bromomethyl)-2-(2,2,2-Trifluoroethoxy)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.