Description

1-Acetyl-1H-Pyrazole-4-Boronic Acid, Pinacol Ester is a high-value, protected boronic acid ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in its stability and reactivity, making it a superior reagent for Suzuki-Miyaura cross-coupling reactions compared to its free boronic acid counterpart. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex heterocyclic scaffolds for active ingredient development. The CAS number for this compound is 1150561-76-4.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in creating pyrazole-containing molecules for oncology, inflammation, and CNS disorders.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Material Science: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and other functional polymers.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of activity-based probes and inhibitors.
• Academic & Contract Research: A staple reagent in university and CRO laboratories for methodological development and exploring new chemical space.
• Scale-up Process Chemistry: Suitable for transition from milligram-scale discovery to multi-kilogram production under optimized conditions.

Basic Information

Item	Detail
Product Name	1-Acetyl-1H-Pyrazole-4-Boronic Acid, Pinacol Ester
CAS No.	1150561-76-4
Molecular Formula	C11H17BN2O3
Molecular Weight	236.08 g/mol
Synonyms	1-Acetyl-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetic Acid; 1-Acetyl-4-(pinacolboranyl)-1H-pyrazole; 1H-Pyrazole-4-boronic acid, 1-acetyl-, pinacol ester; Pyrazole-4-boronic acid pinacol ester, N-acetylated
EINECS	Contact for details

Quality Control

Every batch of 1-Acetyl-1H-Pyrazole-4-Boronic Acid, Pinacol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity, and impurity profile. Our quality commitment supports your regulatory needs for pre-clinical and process development stages.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product in a freezer at -20°C under an inert atmosphere (argon or nitrogen) to prevent oxidation and hydrolysis. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.