Description

2-Cyano-3-Methylpyridine-5-Boronic Acid,Pinacol Ester is a high-value, multifunctional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Material Science Research: Serves as a precursor for creating functionalized organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and binding studies.
• Catalyst Ligand Development: Utilized to construct novel, sophisticated ligand frameworks for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	2-Cyano-3-Methylpyridine-5-Boronic Acid,Pinacol Ester
CAS No.	1150561-70-8
Molecular Formula	C14H17BN2O2
Molecular Weight	256.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methylpicolinonitrile; 3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile; 2-Cyano-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Methyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile; Boronic acid, B-(2-cyano-3-methyl-5-pyridinyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Cyano-3-Methylpyridine-5-Boronic Acid,Pinacol Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive coupling reactions. Our quality control protocols include HPLC, NMR, and MS to verify identity, purity, and the absence of critical impurities like palladium. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect this moisture-sensitive compound from atmospheric humidity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.