Description

4,4,5,5-Tetramethyl-2-(3-Methyl-5-(Trifluoromethoxy)-Phenyl)-1,3,2-Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it provides a stable and reactive handle for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and materials science industries for the efficient synthesis of novel active ingredients and functional molecules. CAS No. 1150561-56-0.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethoxy-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Enables the creation of organic electronic materials, such as those used in OLEDs and organic photovoltaics, via palladium-catalyzed coupling.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving diverse industrial clients.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-Methyl-5-(Trifluoromethoxy)-Phenyl)-1,3,2-Dioxaborolane
CAS No.	1150561-56-0
Molecular Formula	C14H18BF3O3
Molecular Weight	302.10 g/mol
Synonyms	(3-Methyl-5-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 2-(3-Methyl-5-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methyl-5-(trifluoromethoxy)benzeneboronic acid pinacol ester; Pinacol [3-Methyl-5-(trifluoromethoxy)phenyl]boronate; [3-Methyl-5-(trifluoromethoxyphenyl)]boronic acid pinacol ester; Boronic acid, B-[3-methyl-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(3-Methyl-5-(Trifluoromethoxy)-Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) with detailed specifications are provided for each lot to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.