Description

2-Acetamido-5-Nitrophenylboronic Acid,Pinacol Ester is a specialized boronic acid derivative, a crucial building block in modern synthetic chemistry. Its value lies in its dual functionality, where the protected boronic acid group serves as a key handle for Suzuki-Miyaura cross-coupling reactions, while the acetamido and nitro substituents offer versatile sites for further chemical modification. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those requiring biaryl linkages formed via palladium-catalyzed cross-coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that incorporate nitrophenyl and boronate functional groups.
• Material Science: Serves as a monomer or building block for creating advanced polymers, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Utilized in the design of molecular probes and sensors that leverage boronic acid chemistry for saccharide or analyte recognition.
• Academic & Contract Research: Essential for methodological development in organic synthesis and catalysis research within university and CRO laboratories.
• Dye & Pigment Synthesis: Acts as an intermediate for creating specialized azo dyes and pigments where the nitro and acetamido groups influence color and stability.

Basic Information

Product Name	2-Acetamido-5-Nitrophenylboronic Acid,Pinacol Ester
CAS No.	1150271-73-0
Molecular Formula	C14H19BN2O5
Molecular Weight	306.12 g/mol
Synonyms	5-Nitro-2-acetamidophenylboronic acid pinacol ester; 2-Acetamido-5-nitrophenylboronic acid pinacol ester; (2-Acetamido-5-nitrophenyl)boronic acid pinacol ester; 2-Acetamido-5-nitrophenyl-Bpin; B-(2-Acetamido-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[2-acetamido-5-nitrophenyl]-1,3,2-dioxaborolane; N-[5-Nitro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide
EINECS	Contact for details

Quality Control

Our 2-Acetamido-5-Nitrophenylboronic Acid,Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment ensures material consistency, which is critical for reproducible results in sensitive cross-coupling reactions and multi-step syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.