Description

Methyl2,2-Difluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D][1,3]Dioxole-5-Carboxylate is a high-value, multi-functional chemical building block featuring both a benzo[d][1,3]dioxole core and a pinacol boronate ester group. This compound is engineered to serve as a critical intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling reactions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its difluoro and boronate functionalities.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Employed in the synthesis of complex ligands for catalysis and in the development of novel organoboron catalysts.
• Chemical Biology Probes: Utilized to create tagged molecules and probes for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic ester derivatives.

Basic Information

Product Name	Methyl2,2-Difluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D][1,3]Dioxole-5-Carboxylate
CAS No.	1150271-58-1
Molecular Formula	C₁₇H₂₁BF₂O₆
Molecular Weight	370.16 g/mol
Synonyms	Methyl 2,2-Difluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole-5-carboxylate; 5-(Methoxycarbonyl)-2,2-difluorobenzo[d][1,3]dioxole-7-boronic acid pinacol ester; 2,2-Difluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-benzodioxole-5-carboxylic acid methyl ester; 1150271-58-1; Benzo[d][1,3]dioxole-5-carboxylic acid, 2,2-difluoro-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 2,2-difluoro-7-(pinacolatoboryl)benzo[d][1,3]dioxole-5-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl2,2-Difluoro-7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzo[D][1,3]Dioxole-5-Carboxylate is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and GC analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.