Description

n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, a key functional handle for modern cross-coupling reactions. This compound is specifically engineered to enable the efficient synthesis of complex molecules, offering researchers and manufacturers a reliable building block for drug discovery and development. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical boron-containing reagent for constructing biaryl and heterobiaryl scaffolds prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Employed in the development of new generation herbicides and fungicides that require the incorporation of the trifluoromethoxy-phenyl moiety.
• Material Science Research: Acts as a precursor for creating organic electronic materials and liquid crystals due to its conjugated aromatic system and functional handles.
• Chemical Biology & Proteomics: Can be utilized as a building block for activity-based probes or protein labeling agents, leveraging the reactivity of the boronate ester.
• Contract Research & Manufacturing (CRO/CMO): A standard item for organizations providing custom synthesis and process scale-up services for the life sciences industry.

Basic Information

Item	Details
Product Name	n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Phenyl)Acetamide
CAS No.	1150271-56-9
Molecular Formula	C15H19BF3NO4
Molecular Weight	345.12 g/mol
Synonyms	2-Acetamido-4-(trifluoromethoxy)phenylboronic acid pinacol ester; 2-Acetamido-4-trifluoromethoxyphenylboronic acid pinacol ester; N-[2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)phenyl]acetamide; 1150271-56-9; Acetamide, N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Every batch of n-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Phenyl)Acetamide is manufactured and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure the material meets the exacting standards required for research and cGMP manufacturing. Our quality protocols are designed to support regulatory filings and ensure supply chain reliability for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.