Description

Methyl2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-7-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a versatile pinacol boronate ester functional group. This compound is critical for enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern medicinal chemistry and drug discovery. It is primarily utilized by research institutions and pharmaceutical manufacturers for the synthesis of complex, biologically active molecules, including potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boron-containing coupling partner for forming carbon-carbon bonds between aromatic systems.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize lead compounds.
• Organic Synthesis Research: Enables the construction of complex indole-based heterocycles and functionalized molecules in academic and industrial R&D settings.
• Agrochemical Development: Employed in the research and synthesis of new crop protection agents and herbicides.
• Material Science Precursor: Potential use in the development of organic electronic materials and functional polymers.

Basic Information

Product Name	Methyl2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-7-Carboxylate
CAS No.	1150271-42-3
Molecular Formula	C₁₆H₂₀BNO₄
Molecular Weight	301.15 g/mol
Synonyms	Methyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxylate; 7-Methoxycarbonyl-2-indoleboronic acid pinacol ester; 1H-Indole-7-carboxylic acid, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; Methyl 2-(pinacolatoboryl)-1H-indole-7-carboxylate; 2-(Pinacolboron)indole-7-carboxylic acid methyl ester; 1150271-42-3
EINECS	Contact for details

Quality Control

Our Methyl2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole-7-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to guarantee traceability and compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.