Description

3-(T-Butyldimethysilyloxy)-5-Trifluoromethoxyphenylboronic Acid,Pinacol Ester is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. Its core value lies in the synergistic protection of reactive sites, combining a silyl ether and a boronic ester, which provides exceptional stability and selectivity for complex coupling reactions. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients. Its unique structure facilitates the construction of complex molecular architectures that are otherwise difficult to access.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing complex drug candidates, particularly those containing trifluoromethoxy and protected phenol motifs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the trifluoromethoxy group often enhances biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, or metal-organic frameworks (MOFs) with tailored properties.
• Complex Molecule Construction: Enables the precise, sequential functionalization of aromatic rings in multi-step synthetic routes for natural products and specialty chemicals.
• Process Chemistry Development: Valued in scale-up and route scouting for its improved handling characteristics compared to more labile boronic acids.

Basic Information

Product Name	3-(T-Butyldimethysilyloxy)-5-Trifluoromethoxyphenylboronic Acid,Pinacol Ester
CAS No.	1150271-36-5
Molecular Formula	C₁₈H₂₈BF₃O₃Si
Molecular Weight	388.31 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]-5-(trifluoromethoxy)benzeneboronic acid pinacol ester; 5-(Trifluoromethoxy)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]benzeneboronic acid pinacol ester; 3-(tert-Butyldimethylsiloxy)-5-trifluoromethoxyphenylboronic acid pinacol ester; 3-TBDMSO-5-trifluoromethoxyphenylboronic acid pinacol ester; 3-(Tert-butyldimethylsilyloxy)-5-(trifluoromethoxy)phenylboronic acid pinacol ester; Boronic acid, B-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester; 3-(tert-Butyldimethylsilyloxy)-5-trifluoromethoxyphenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 3-(T-Butyldimethysilyloxy)-5-Trifluoromethoxyphenylboronic Acid,Pinacol Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR (¹H, ¹³C, ¹¹B, ¹⁹F) for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.