Description

4-Chloro-3-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Pyridine, HCl is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a chloro substituent and a protected boronic ester group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially for kinase inhibitors and other targeted small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety serves as a crucial handle for forming carbon-carbon bonds, a fundamental step in constructing complex molecular architectures.
• Agrochemical Research: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Material Science & OLED Development: Acts as a building block for creating novel organic electronic materials and emissive layers in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and tools for studying biological pathways and protein functions.

Basic Information

Product Name	4-Chloro-3-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Pyridine, HCl
CAS No.	1150271-27-4
Molecular Formula	C11H16BClNO2•HCl
Molecular Weight	278.42 g/mol (Free base: 241.51 g/mol)
Synonyms	4-Chloro-3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyridine hydrochloride; 2-(4-Chloropyridin-3-yl)-5,5-dimethyl-1,3,2-dioxaborinane hydrochloride; 3-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-4-chloropyridine HCl; 4-Chloro-3-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)pyridinium chloride; Boronic ester pyridine hydrochloride intermediate; CAS 1150271-27-4
EINECS	Contact for details

Quality Control

Our production of 4-Chloro-3-(5,5-Dimethyl-1,3,2-Dioxaborinan-2-Yl)Pyridine, HCl adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.