Description

3-Chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a high-value, multi-functional boronic ester derivative of pyridine, serving as a critical synthetic intermediate. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures in advanced research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated heterocyclic structures.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs) due to its boronic ester functional group.
• Suzuki-Miyaura Cross-Coupling Reactions: The primary application is as a versatile coupling partner to form carbon-carbon bonds between the pyridine ring and various aryl or vinyl groups.
• Chemical Biology & Proteomics: Can be utilized in the development of molecular probes and inhibitors for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis projects and scale-up processes under GMP or non-GMP conditions.

Basic Information

Product Name	3-Chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.	1150114-69-4
Molecular Formula	C14H21BClNO3
Molecular Weight	297.58 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-chloro-2-isopropoxypyridine; 3-Chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Isopropoxy-3-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Chloro-2-(propan-2-yloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol ester of (3-chloro-2-isopropoxypyridin-5-yl)boronic acid; CAS 1150114-69-4.
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR (1H, 13C, 11B), HPLC, and GC analysis, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ISO 9001 standards, and we support development under ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and easily oxidized nature, this material should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.