Description

5-(T-Butyldimethylsilyloxy)-2,3-Difluorophenylboronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. This compound matters because it combines the stability of a silyl-protected phenol with the versatile reactivity of an arylboronic acid, enabling precise cross-coupling reactions under mild conditions. It is primarily needed by pharmaceutical and agrochemical R&D teams for constructing complex fluorinated aromatic scaffolds, which are critical in developing new active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used to incorporate the difluorophenol moiety into advanced pesticide and herbicide molecules, improving their environmental profile and efficacy.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated aromatic cores in electronic and optoelectronic materials.
• Polymer Chemistry: Enables the synthesis of specialty fluorinated polymers with unique thermal and chemical resistance properties.
• Chemical Biology & Probe Development: Utilized in creating tagged molecules and bioconjugates for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for CROs and CDMOs offering bespoke synthesis services for complex organic molecules.

Basic Information

Item	Details
Product Name	5-(T-Butyldimethylsilyloxy)-2,3-Difluorophenylboronic Acid
CAS No.	1150114-45-6
Molecular Formula	C₁₂H₁₉BF₂O₃Si
Molecular Weight	288.18 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]-2,3-difluorophenylboronic Acid; 2,3-Difluoro-5-[(tert-butyldimethylsilyl)oxy]benzeneboronic Acid; 5-(TBDMSO)-2,3-Difluorophenylboronic Acid; 5-(tert-Butyl(dimethyl)silyloxy)-2,3-difluorophenylboronic Acid; 2,3-Difluoro-5-hydroxybenzeneboronic Acid TBDMS Ether; 5-(Tert-Butyldimethylsiloxy)-2,3-Difluorophenylboronic Acid; B-[5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2,3-difluorophenyl]boronic Acid
EINECS	Contact for details

Quality Control

Our 5-(T-Butyldimethylsilyloxy)-2,3-Difluorophenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.