Description

Bromo-Peg3-Phosphonic Acid Ethyl Ester is a high-purity bifunctional organic intermediate featuring a reactive bromoalkyl terminus and a phosphonic acid ethyl ester group, connected by a triethylene glycol (PEG3) spacer. This unique structure makes it a critical building block for the synthesis of complex molecules, particularly in pharmaceutical and bioconjugation chemistry. It is primarily utilized by researchers and process chemists in drug discovery and development, where it serves as a versatile linker for creating targeted drug conjugates, prodrugs, and functionalized materials.

Application

• Pharmaceutical Linker Chemistry: A key reagent for constructing antibody-drug conjugates (ADCs), peptide-drug conjugates, and other targeted therapeutics.
• Prodrug Synthesis: Used to introduce a phosphonate prodrug moiety, enhancing drug solubility and enabling controlled release.
• Bioconjugation & Labeling: Facilitates the attachment of dyes, probes, or other functional groups to biomolecules via the reactive bromo handle.
• Material Science & Surface Modification: Employed to functionalize surfaces, nanoparticles, or polymers with phosphonate groups for improved biocompatibility or specific binding properties.
• Medicinal Chemistry & Library Synthesis: Serves as a versatile scaffold for generating diverse compound libraries in early-stage drug discovery.
• Nucleotide & Oligonucleotide Analog Development: Used in the synthesis of modified nucleotides or as a non-hydrolyzable linker in oligonucleotide constructs.

Basic Information

Product Name	Bromo-Peg3-Phosphonic Acid Ethyl Ester
CAS No.	1148026-98-5
Molecular Formula	C9H20BrO6P
Molecular Weight	335.13 g/mol
Synonyms	3-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)propylphosphonic acid diethyl ester; Diethyl (8-bromo-3,6-dioxaoctyl)phosphonate; Bromo-PEG3-phosphonate diethyl ester; 8-Bromo-3,6-dioxaoctylphosphonic acid diethyl ester; 2-[2-[2-(2-Bromoethoxy)ethoxy]ethoxy]ethylphosphonic acid diethyl ester; Bromo(triethylene glycol)propylphosphonate ethyl ester; Br-PEG3-P(O)(OEt)2; Bromo-PEG3-phosphonate
EINECS	Contact for details

Quality Control

Our Bromo-Peg3-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.