Description

2-Ethoxy-Pyrimidine-5-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds to construct complex pyrimidine-containing molecules.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with pyrimidine cores.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated structure.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and molecular probes for biochemical and diagnostic applications.
• Process Chemistry & Scale-up: The pinacol ester group offers improved stability, making it suitable for larger-scale manufacturing processes.

Basic Information

Product Name	2-Ethoxy-Pyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1147105-68-7
Molecular Formula	C12H19BN2O3
Molecular Weight	250.11 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethoxypyrimidine; 2-Ethoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Ethoxypyrimidin-5-ylboronic acid pinacol ester; 5-Borono-2-ethoxypyrimidine pinacol ester; (2-Ethoxypyrimidin-5-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-Pyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR and HPLC to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent hydrolysis of the boronic ester.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.