Description

2-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Indazole is a high-value, multi-functional chemical building block designed for advanced organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly in the construction of complex heterocyclic scaffolds. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel indazole-based drug candidates targeting various therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the indazole core for biological activity.
• Material Science: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying biological pathways and protein function.
• Academic & Contract Research: Essential for methodology development and library synthesis in academic laboratories and CROs (Contract Research Organizations).
• Custom Synthesis: A versatile starting point for the custom manufacturing of complex, boronate-containing target molecules.

Basic Information

Product Name	2-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Indazole
CAS No.	1146955-35-2
Molecular Formula	C18H25BN2O3
Molecular Weight	328.22 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(tetrahydro-2H-pyran-2-yl)-2H-indazole; 2H-Indazole, 2-(tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 2-(THP)-4-(Pinacol boronate)-2H-indazole; 2-(Tetrahydropyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole; 4-BPin-2-THP-2H-indazole; CAS 1146955-35-2
EINECS	Contact for details

Quality Control

Every batch of 2-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2H-Indazole is manufactured and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure compliance with stringent purity specifications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.