Description

(R)-3-Cyclopentyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanenitrile is a high-purity, chiral boronic ester building block designed for advanced pharmaceutical and agrochemical research. This compound is critical for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex, optically active molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new, more effective pesticides and herbicides with specific stereochemical requirements.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester reagent for forming carbon-carbon bonds in complex molecule assembly.
• Asymmetric Synthesis: Leverages its (R)-chirality for the construction of stereogenic centers in target molecules.
• Ligand and Catalyst Development: A precursor for creating novel chiral ligands and organometallic catalysts.
• Material Science Research: Potential building block for advanced organic electronic materials and polymers.
• Process Chemistry: Used in route scouting and optimization for the scalable production of fine chemicals.
• Academic Research: A valuable tool for methodological studies in synthetic organic chemistry.

Basic Information

Product Name	(R)-3-Cyclopentyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanenitrile
CAS No.	1146629-84-6
Molecular Formula	C17H26BN3O2
Molecular Weight	315.22 g/mol
Synonyms	(R)-3-Cyclopentyl-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanenitrile; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-propanenitrile, 3-cyclopentyl-, (3R)-; (R)-3-Cyclopentyl-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)propionitrile; (R)-3-Cyclopentyl-3-(4-(pinacolatoboron)-1H-pyrazol-1-yl)propanenitrile; (R)-Cyclopentyl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetonitrile; 1146629-84-6; (R)-Boronic acid, [1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our (R)-3-Cyclopentyl-3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanenitrile is manufactured under strict quality control protocols to ensure high chiral purity and chemical integrity. Each batch is analyzed using advanced techniques including HPLC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) detailing all specifications are provided and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (nitrogen or argon) when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.