Description

1H-Pyrazole, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is a sophisticated, multi-functional organic building block that combines a pyrazole core with both a boronic ester pinacol group and a SEM (2-(trimethylsilyl)ethoxymethyl) protecting group. This compound matters as a critical intermediate in modern synthetic chemistry, enabling precise cross-coupling reactions and protecting group strategies essential for constructing complex molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of active ingredients, as well as by advanced material scientists developing novel functional polymers and ligands.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heteroaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging the reactivity of the boronic ester moiety.
• Material Science Research: Serves as a precursor for creating functional organic frameworks, polymers, and ligands for catalysis.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.
• Academic & Industrial R&D: A versatile reagent for methodological development in organic synthesis and catalysis research.
• Semiconductor Precursor: Potential use in the development of organic electronic materials and deposition processes.

Basic Information

Product Name	1H-Pyrazole, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]-
CAS No.	1146162-54-0
Molecular Formula	C15H29BN2O3Si
Molecular Weight	336.31 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole; 1-((2-(Trimethylsilyl)ethoxy)methyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 3-(Pinacolboryl)-1-SEM-pyrazole; 1-SEM-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; Pyrazole-3-boronic acid pinacol ester, SEM-protected; SEM-Pyrazole-3-Bpin
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole, 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-[[2-(Trimethylsilyl)Ethoxy]Methyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with ISO standards and the stringent requirements of pharmaceutical and advanced material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use. Recommended long-term storage temperature is 2-8°C (refrigerated) or -20°C for extended periods.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.