Description

1-(Tetrahydro-2H-Pyran-2-Yl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is a versatile and high-value boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to construct complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in constructing heterocyclic cores.
• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group acts as a stable, reactive handle for palladium-catalyzed coupling with aryl/heteroaryl halides.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring specific pyrazole-based structures.
• Material Science: Intermediate in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Probe Development: Utilized for synthesizing molecular probes and labeled compounds for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring specialized boronic esters.

Basic Information

Product Name	1-(Tetrahydro-2H-Pyran-2-Yl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	1141878-27-4
Molecular Formula	C15H25BN2O3
Molecular Weight	292.19 g/mol
Synonyms	4-Methyl-1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(THP)-4-Methyl-5-(pinacolboron)pyrazole; 4-Methyl-1-(tetrahydropyran-2-yl)-1H-pyrazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(tetrahydro-2H-pyran-2-yl)-4-methyl-1H-pyrazole; Pyrazole boronic ester, THP-protected; CAS 1141878-27-4
EINECS	Contact for details

Quality Control

Every batch of our 1-(Tetrahydro-2H-Pyran-2-Yl)-4-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure reliable performance in sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and LC-MS are available upon request and accompany every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and reactivity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.