Description

2,6H-Trifluoroacetanilide is a specialized fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for introducing the trifluoroacetyl aniline moiety into more complex molecular architectures. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients, where its unique fluorine-containing structure can enhance metabolic stability and bioavailability.

Application

• As a crucial pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders.
• Used in agrochemical research for developing new herbicides and pesticides with improved efficacy and environmental profiles.
• Serves as a versatile building block in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Employed in the synthesis of advanced materials, such as liquid crystals and organic semiconductors, where fluorination tunes electronic properties.
• Acts as a precursor for custom synthesis and contract manufacturing of fluorinated fine chemicals.

Basic Information

Product Name	2,6H-Trifluoroacetanilide
CAS No.	1140391-90-7
Molecular Formula	C8H6F3NO
Molecular Weight	189.14 g/mol
Synonyms	N-(2,6-Difluorophenyl)-2,2,2-trifluoroacetamide; 2',6'-Difluoro-2,2,2-trifluoroacetamilide; 2,6-Difluorophenyltrifluoroacetamide; 2,2,2-Trifluoro-N-(2,6-difluorophenyl)acetamide; α,α,α-Trifluoro-2',6'-difluoroacetamilide; TFAA-2,6-difluoroaniline derivative
EINECS	Contact for details

Quality Control

Our 2,6H-Trifluoroacetanilide is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.