Description

4-(1,1-Difluoroethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. This compound matters for its unique structure, which provides exceptional stability and reactivity, making it a critical intermediate in the development of sophisticated materials and active ingredients. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries seeking to incorporate fluorinated motifs for enhanced performance.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a fluorinated core structure in the production of high-performance electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, and surface properties for advanced coatings and engineering plastics.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, fluorinated molecular architectures.

Basic Information

Product Name	4-(1,1-Difluoroethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene
CAS No.	1138445-20-1
Molecular Formula	C9H6F6
Molecular Weight	228.14 g/mol
Synonyms	1-Fluoro-4-(1,1-difluoroethyl)-2-(trifluoromethyl)benzene; 1,2,4-Trifluorobenzene, 5-(1,1-difluoroethyl)-2-(trifluoromethyl)-; 5-(1,1-Difluoroethyl)-2-(trifluoromethyl)-1,2,4-trifluorobenzene; α,α-Difluoro-4-fluoro-α-methyl-2-(trifluoromethyl)benzene; 4-Fluoro-α,α-difluoro-α-methyl-2-(trifluoromethyl)benzene; DFETFB; (1,1-Difluoroethyl)-fluorotrifluoromethylbenzene
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoroethyl)-1-Fluoro-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its properties as a strong acid/organic solvent and high volatility, ensure containers are kept tightly sealed and away from heat, sparks, and open flames. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.