Description

1-Chloro-4-(1,1-Difluoroethyl)-2,5-Difluorobenzene is a high-purity, multi-functional fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and difluoroethyl substituents on a difluorobenzene core, makes it a versatile intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Organic Electronics: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research: A valuable reagent for academic and industrial research in organofluorine chemistry and medicinal chemistry.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development and scale-up projects.

Basic Information

Product Name	1-Chloro-4-(1,1-Difluoroethyl)-2,5-Difluorobenzene
CAS No.	1138444-89-9
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	2,5-Difluoro-1-chloro-4-(1,1-difluoroethyl)benzene; 1-Chloro-2,5-difluoro-4-(1,1-difluoroethyl)benzene; 4-Chloro-2,5-difluoro-α,α-difluorotoluene; Benzene, 1-chloro-4-(1,1-difluoroethyl)-2,5-difluoro-; (1,1-Difluoroethyl)-2,5-difluorochlorobenzene
EINECS	Contact for details

Quality Control

Our production of 1-Chloro-4-(1,1-Difluoroethyl)-2,5-Difluorobenzene adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) to verify identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment, ensuring full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.