Description

2-Bromo-4-(1,1-Difluoroethyl)-1-Fluorobenzene is a high-value, multi-halogenated aromatic building block designed for advanced synthetic chemistry. This compound is critical for introducing specific halogenated motifs into complex molecular architectures, enabling precise control over electronic and steric properties. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoroethyl and halogenated phenyl groups contribute to biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions due to the reactive bromine atom, facilitating carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry: A valuable reagent for studying structure-activity relationships (SAR) in medicinal chemistry, leveraging the unique properties of fluorine atoms to modulate lipophilicity, metabolic stability, and binding affinity.
• Chemical Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling in related chemical processes.

Basic Information

Product Name	2-Bromo-4-(1,1-Difluoroethyl)-1-Fluorobenzene
CAS No.	1138444-85-5
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	1-Bromo-2-fluoro-5-(1,1-difluoroethyl)benzene; 2-Fluoro-5-(1,1-difluoroethyl)bromobenzene; 1-Fluoro-2-bromo-4-(1,1-difluoroethyl)benzene; 4-(1,1-Difluoroethyl)-2-bromo-1-fluorobenzene; Benzene, 2-bromo-4-(1,1-difluoroethyl)-1-fluoro-; α,α-Difluoro-2-bromo-4-fluoroethylbenzene (common name); 2-Bromo-1-fluoro-4-(1,1-difluoroethyl)benzene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including GC, HPLC, NMR, and MS to confirm identity, purity, and the absence of critical impurities. We adhere to a comprehensive quality management system and can provide supporting documentation, including detailed Certificates of Analysis (COA), upon request to meet the stringent requirements of our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Handle and store under an inert atmosphere if prolonged storage is required to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.