Description

2-(3-Chlorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a crucial organoboron building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a key intermediate in developing active ingredients, functional polymers, and organic electronic components.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing biphenyl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific chlorobenzyl-containing architectures.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through structure-activity relationship (SAR) studies and library synthesis.
• Catalyst & Ligand Development: Acts as a precursor for creating novel palladium catalyst ligands or other organometallic complexes.
• Custom Synthesis & Contract Manufacturing: A vital reagent for fine chemical and custom synthesis houses serving the life sciences industry.

Basic Information

Item	Details
Product Name	2-(3-Chlorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1138077-59-4
Molecular Formula	C₁₃H₁₈BClO₂
Molecular Weight	252.54 g/mol
Synonyms	(3-Chlorobenzyl)boronic acid pinacol ester; 1-[(3-Chlorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Chlorobenzylboronic acid pinacol ester; Pinacol (3-chlorobenzyl)boronate; (3-Chlorobenzyl)Bpin; B-(3-Chlorobenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-ChlorobenzylBPin
EINECS	Contact for details

Quality Control

Our 2-(3-Chlorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC/GC)	≥97.0%
Purity (by NMR)	≥95.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.