Description

7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydronaphthalen-1(2H)-One is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex carbon-carbon bonds. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those with tetrahydronaphthalene or related scaffolds.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient formation of biaryl and other C-C bonds in the presence of a palladium catalyst, essential for constructing complex molecular architectures.
• Organic Synthesis Research: Used in academic and industrial R&D laboratories for developing new synthetic methodologies and exploring novel chemical space.
• Agrochemical Development: Serves as an intermediate in the research and synthesis of new crop protection agents and herbicides.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials, such as those for OLEDs or conductive polymers, where precise molecular structure is required.

Basic Information

Product Name	7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydronaphthalen-1(2H)-One
CAS No.	1135871-91-8
Molecular Formula	C16H21BO3
Molecular Weight	272.15 g/mol
Synonyms	7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydronaphthalen-1(2H)-one; 1-Oxo-1,2,3,4-tetrahydronaphthalene-7-boronic acid pinacol ester; 7-(Pinacolboryl)-3,4-dihydro-1(2H)-naphthalenone; 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydro-1-naphthalenone; 7-Borono-3,4-dihydro-1(2H)-naphthalenone pinacol ester; 7-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydronaphthalen-1(2H)-one
EINECS	Contact for details

Quality Control

Our production of 7-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydronaphthalen-1(2H)-One adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed via HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.