Description

3-(5-Bromo-1-Benzofuran-2-Yl)-3-Oxopropanenitrile is a high-purity, specialized organic building block featuring a benzofuran core functionalized with bromine and a cyanoacetyl group. This compound is of significant value for its role as a key synthetic intermediate in the development of novel pharmacologically active molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for constructing complex heterocyclic scaffolds in drug discovery and material science programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of potential drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its halogenated benzofuran structure.
• Material Science: Acts as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated π-system.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) where the bromine atom serves as a reactive handle for further functionalization.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies and the exploration of new chemical spaces in heterocyclic chemistry.

Basic Information

Product Name	3-(5-Bromo-1-Benzofuran-2-Yl)-3-Oxopropanenitrile
CAS No.	1135283-25-8
Molecular Formula	C₁₁H₆BrNO₂
Molecular Weight	264.08 g/mol
Synonyms	5-Bromo-2-benzofuranyl cyanomethyl ketone; 3-Oxo-3-(5-bromo-1-benzofuran-2-yl)propanenitrile; 5-Bromo-2-cyanacetylcoumarone; 5-Bromo-2-(2-cyanoacetyl)benzofuran; 2-(5-Bromobenzofuran-2-yl)-2-oxoacetonitrile; (5-Bromo-1-benzofuran-2-yl)(cyano)methanone; 1135283-25-8; 5-Bromo-2-cyanomethylbenzofuran ketone
EINECS	Contact for details

Quality Control

Our 3-(5-Bromo-1-Benzofuran-2-Yl)-3-Oxopropanenitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.