Description

2-Fluoro-4-Hydroxybenzamide is a fluorinated aromatic amide derivative that serves as a versatile and high-value synthetic intermediate. This compound is critical for the development of advanced pharmaceutical agents and agrochemicals, where the introduction of fluorine atoms is a key strategy for modulating biological activity and metabolic stability. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for use in drug discovery, process development, and the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine moiety to enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals where fluorinated aromatic units impart desired thermal and chemical resistance properties.
• Biochemical Probe Synthesis: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and receptor interactions.
• Custom Synthesis and Contract Manufacturing: A starting material for custom synthesis projects requiring specific fluorinated benzamide scaffolds.

Basic Information

Product Name	2-Fluoro-4-Hydroxybenzamide
CAS No.	1133122-96-9
Molecular Formula	C7H6FNO2
Molecular Weight	155.13 g/mol
Synonyms	4-Hydroxy-2-fluorobenzamide; 2-Fluoro-4-hydroxybenzoic acid amide; 2-Fluoro-4-hydroxybenzamide; Benzoic acid, 2-fluoro-4-hydroxy-, amide; 2-Fluoro-4-carbamoylphenol; 4-Aminocarbonyl-3-fluorophenol
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Hydroxybenzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.