Description

Boronic Acid, B-[(1S)-3-Methyl-1-[[(2R)-1-Oxo-3-Phenyl-2-[(2-Pyrazinylcarbonyl)Amino]Propyl]Amino]Butyl]- is a sophisticated chiral boronic acid derivative designed for advanced synthetic applications. This compound is a critical building block in modern pharmaceutical research, particularly for the development of protease inhibitors and other targeted therapeutics. It is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries who require high-purity, structurally complex intermediates for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel protease inhibitors, including potential treatments for viral infections and certain cancers.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical organoboron reagent for forming carbon-carbon bonds in the construction of complex, drug-like molecules.
• Peptidomimetic Research: Used in the design and synthesis of peptide analogs to enhance stability, bioavailability, and target specificity.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric transformations to introduce stereogenic centers with high enantiomeric purity.
• Bioconjugation Chemistry: Potential utility in labeling and modifying biomolecules due to its reactive boronic acid moiety and functional handles.
• Chemical Biology Probes: Development of activity-based probes for studying enzyme function and mechanism in biological systems.

Basic Information

Item	Detail
Product Name	Boronic Acid, B-[(1S)-3-Methyl-1-[[(2R)-1-Oxo-3-Phenyl-2-[(2-Pyrazinylcarbonyl)Amino]Propyl]Amino]Butyl]-
CAS No.	1132709-16-0
Molecular Formula	C20H25BN4O3
Molecular Weight	380.26 g/mol
Synonyms	(S)-3-Methyl-1-(((R)-1-oxo-3-phenyl-2-(pyrazine-2-carboxamido)propyl)amino)butylboronic Acid; B-[(1S)-3-Methyl-1-[[(2R)-1-Oxo-3-Phenyl-2-[(Pyrazine-2-carbonyl)Amino]Propyl]Amino]Butyl]Boronic Acid; Chiral Phenylalanine-Pyrazine Boronic Acid Derivative; Protease Inhibitor Boronic Acid Intermediate; (S,R)-Peptidyl Boronic Acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-[(1S)-3-Methyl-1-[[(2R)-1-Oxo-3-Phenyl-2-[(2-Pyrazinylcarbonyl)Amino]Propyl]Amino]Butyl]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. We provide full traceability and Certificates of Analysis (COA) detailing all specifications to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.