Description

((S)-3-Methyl-1-((S)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanamido)Butyl)Boronic Acid is a sophisticated chiral boronic acid derivative designed for advanced pharmaceutical research and development. This compound serves as a critical high-purity building block in the synthesis of complex molecules, particularly for protease inhibitors and other targeted therapeutics. It is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require precise stereochemistry and reliable quality for their synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel protease inhibitors and other active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its defined stereochemistry.
• Bioconjugation & Probe Development: Utilized in the development of chemical probes and bioconjugates leveraging boronic acid chemistry for target engagement.
• Process Chemistry & Scale-up: Serves as a critical starting material or intermediate in the development and optimization of commercial-scale synthetic processes.
• Academic Research: Employed in university and institutional labs for studying asymmetric synthesis, boron chemistry, and novel catalytic reactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting drug discovery and development programs for global clients.

Basic Information

Item	Detail
Product Name	((S)-3-Methyl-1-((S)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanamido)Butyl)Boronic Acid
CAS No.	1132709-14-8
Molecular Formula	C19H24BN5O3
Molecular Weight	381.24 g/mol
Synonyms	(S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid; (2S)-3-Methyl-1-[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoylamino]butylboronic acid; Bortezomib Intermediate; Boronic acid derivative CAS 1132709-14-8; Protease inhibitor intermediate; Chiral boronic acid peptide derivative
EINECS	Contact for details

Quality Control

Our ((S)-3-Methyl-1-((S)-3-Phenyl-2-(Pyrazine-2-Carboxamido)Propanamido)Butyl)Boronic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing including HPLC, NMR, and chiral purity analysis to ensure identity, potency, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all relevant specifications. We support development needs with custom purity grades and documentation suitable for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.