Description

tert-Butyl 4-(3-Cyano-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate is a high-value, multi-functional chemical building block designed for advanced organic synthesis. Its core value lies in combining a protected piperazine moiety with a boronic ester pinacol group, enabling efficient cross-coupling reactions and modular molecular construction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients through Suzuki-Miyaura coupling and other palladium-catalyzed transformations.

Application

• Key intermediate in the synthesis of pharmaceutical candidates, especially those targeting central nervous system (CNS) disorders.
• Building block for constructing complex molecules in medicinal chemistry via Suzuki-Miyaura cross-coupling reactions.
• Precursor for the development of novel agrochemicals and fine chemicals requiring specific piperazine-based architectures.
• Used in research and development for creating libraries of compounds for high-throughput screening.
• Intermediate in the synthesis of ligands for catalysis and materials science applications.
• Starting material for the preparation of active pharmaceutical ingredients (APIs) with improved pharmacokinetic properties.

Basic Information

Product Name	tert-Butyl 4-(3-Cyano-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate
CAS No.	1129541-91-8
Molecular Formula	C22H32BN3O4
Molecular Weight	413.32 g/mol
Synonyms	1-Boc-4-(3-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; tert-Butyl 4-[3-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 2-[3-(4-Boc-piperazin-1-yl)-5-cyanophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1,1-Dimethylethyl 4-[3-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1-piperazinecarboxylate; BOC-Piperazine-Boronic Acid Pinacol Ester Derivative; 1129541-91-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(3-Cyano-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.