Description

tert-Butyl 4-(3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core and a boronic ester pinacol group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for constructing biaryl and heterobiaryl structures in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research, development, and scale-up synthesis of novel small molecule drugs.
• Proteolysis Targeting Chimera (PROTAC) Development: Acts as a versatile linker component due to its piperazine moiety, connecting E3 ligase ligands to target protein binders.
• Chemical Biology & Probe Synthesis: Employed to create molecular probes for target identification and validation in biological systems.
• Library Synthesis for High-Throughput Screening: Used to generate diverse compound libraries to identify new lead structures in drug discovery campaigns.
• Process Chemistry & Route Scouting: Provides a stable, crystalline intermediate for optimizing robust and scalable synthetic routes to final drug substances.

Basic Information

Product Name	tert-Butyl 4-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylate
CAS No.	1129541-83-8
Molecular Formula	C21H32BFN2O4
Molecular Weight	406.30 g/mol
Synonyms	1-Boc-4-(3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine; tert-Butyl 4-[3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperazine-1-carboxylate; 3-Fluoro-5-(1-Boc-piperazin-4-yl)phenylboronic acid pinacol ester; 1-Boc-4-(3-Fluoro-5-boronophenyl)piperazine pinacol ester; BOC-Piperazine-Boronic Acid Pinacol Ester Derivative; 1129541-83-8; 4-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4-(3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperazine-1-carboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates and aligns with the standards required for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for extended periods to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.