Description

1-Bromo-3-Fluoro-5-(Trifluoromethoxy)Benzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and trifluoromethoxy substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethoxy groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Acts as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its ability to modify electronic properties.
• Polymer & Resin Modification: Employed to synthesize specialty monomers and polymers, imparting desired characteristics like chemical resistance, thermal stability, or specific optical properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to construct complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for studying the effects of multiple fluorine-containing substituents on aromatic systems.

Basic Information

Product Name	1-Bromo-3-Fluoro-5-(Trifluoromethoxy)Benzene
CAS No.	1129541-09-8
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	3-Bromo-5-Fluoro(trifluoromethoxy)benzene; 5-Bromo-1-Fluoro-3-(trifluoromethoxy)benzene; Benzene, 1-bromo-3-fluoro-5-(trifluoromethoxy)-; 1-Bromo-3-fluoro-5-(trifluoromethoxy)benzene; 3-Bromo-5-(trifluoromethoxy)fluorobenzene; 5-Bromo-3-fluorophenyl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Fluoro-5-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly sealed due to the compound's sensitivity to light and potential moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.