Description

2-Fluoro-5-(Trifluoromethyl)-Pyridine-3-Boronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. This compound matters because it enables the precise construction of complex molecules through reliable cross-coupling reactions, such as Suzuki-Miyaura couplings. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated pyridine cores found in active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that benefit from the stability and lipophilicity imparted by the trifluoromethyl and fluoro groups.
• Material Science Research: Serves as a precursor for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: Specifically designed as a stable, air-handleable reagent for palladium-catalyzed Suzuki-Miyaura couplings to form biaryl and heterobiaryl structures.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring advanced fluorinated boronic ester chemistry.

Basic Information

Product Name	2-Fluoro-5-(Trifluoromethyl)-Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1128269-66-8
Molecular Formula	C₁₂H₁₄BF₄NO₂
Molecular Weight	291.05 g/mol
Synonyms	[2-Fluoro-5-(trifluoromethyl)pyridin-3-yl]boronic acid pinacol ester; 2-Fluoro-5-(trifluoromethyl)-3-pyridineboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-5-(trifluoromethyl)pyridine; 2-Fluoro-5-trifluoromethylpyridine-3-boronic acid pinacol ester; 5-Trifluoromethyl-2-fluoro-3-pyridineboronic acid pinacol ester; Pinacol 2-fluoro-5-(trifluoromethyl)pyridine-3-boronate; CAS 1128269-66-8
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Trifluoromethyl)-Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.