Description

3,5-Dimethyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol95% is a high-purity, protected pyrazole boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, offering both a protected nitrogen heterocycle and a stable boronic ester group for efficient cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to construct complex molecular architectures for active ingredient discovery and development. The CAS number for this product is 1126779-11-0.

Application

This versatile boronic ester is a key intermediate in advanced organic synthesis, enabling the construction of complex molecules across several high-value industries.

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for creating pyrazole-containing drug candidates.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group facilitates efficient palladium-catalyzed coupling with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate the pyrazole pharmacophore.
• Material Science Research: Serves as a precursor for creating functional organic molecules used in organic light-emitting diodes (OLEDs) and other advanced materials.
• Chemical Biology & Proteomics: Can be utilized as a handle for bioconjugation or in the synthesis of molecular probes and inhibitors.
• Custom Synthesis & Contract Manufacturing: An important starting material for custom synthesis organizations (CSOs) and CDMOs serving the life sciences sector.

Basic Information

Product Name	3,5-Dimethyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol95%
CAS No.	1126779-11-0
Molecular Formula	C16H27BN2O3
Molecular Weight	306.21 g/mol
Synonyms	1-(Tetrahydro-2H-pyran-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-dimethyl-1H-pyrazole; 3,5-Dimethyl-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-boronic acid pinacol ester; THP-Protected Pyrazole Pinacol Boronate; 1H-Pyrazole-4-boronic acid, 3,5-dimethyl-1-(tetrahydro-2H-pyran-2-yl)-, pinacol ester; 1126779-11-0; Pyrazole boronic ester, THP-protected
EINECS	Contact for details

Quality Control

Our 3,5-Dimethyl-1-(Tetrahydro-2H-Pyran-2-Yl)-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol95% is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development as well as pre-clinical scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.